Anti-Cyclin D1 antibody
产品特性
| Product Cat#: | AB-06-1227 |
| Product type: | Primary antibody |
| Antigen: | Cyclin D1 |
| Immunogen: | Synthetic peptide. |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:1000-1:5000); Immunohistochemistry (1:200-1:1000); Immunocytochemistry (1:500-1:2000); Immunofluorescence (1:50-1:200); Flow Cytometry (1:1000-1:5000); Immunoprecipitation |
| Reactivity: | Human, Mouse, Rat |
| Clonality (clone number): | Monoclonal (SA38-08) |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 1% BSA, 40% glycerol, 0.05% NaN3. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | AI327039 antibody |
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| BCL-1 antibody | |
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| BCL1 antibody | |
| BCL1 oncogene antibody | |
| ccnd1 antibody | |
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| CCND1_HUMAN antibody | |
| cD1 antibody | |
| Cyl 1 antibody | |
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| G1/S-specific cyclin-D1 antibody | |
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靶标信息
Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G1/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Hypophosphorylates RB1 in early G1 phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Exhibits transcriptional corepressor activity with INSM1 on the NEUROD1 and INS promoters in a cell cycle-independent manner.
产品来源
洱畔科技实验室
