Anti-CPT1A Recombinant Rabbit Monoclonal antibody
产品特性
| Product Cat#: | AB-06-5101 |
| Product type: | Primary antibody |
| Antigen: | CPT1A |
| Immunogen: | Recombinant protein within human CPT1A aa 201-773. |
| Molecular weight: | Predicted band size: 88 kDa, Observed band size: 88 kDa |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:500-1:2000); Immunohistochemistry-Paraffin (1:500-1:2000); Flow Cytometry (1:1,000) |
| Reactivity: | Human, Mouse |
| Clonality (clone number): | Monoclonal |
| Form: | Liquid |
| Buffer: | 1*PBS buffer (pH7.4), 40% glycerol, 0.1% BSA, 0.05% NaN3. |
| Concentration: | 1 mg/mL |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | Carnitine O palmitoyltransferase 1 liver isoform antibody |
| Carnitine O palmitoyltransferase I antibody | |
| Carnitine O palmitoyltransferase I liver isoform antibody | |
| Carnitine O-palmitoyltransferase 1 antibody | |
| Carnitine O-palmitoyltransferase I antibody | |
| Carnitine palmitoyltransferase 1A (liver) antibody | |
| Carnitine palmitoyltransferase 1A antibody | |
| Carnitine palmitoyltransferase I antibody | |
| Carnitine palmitoyltransferase I liver antibody | |
| CPT 1 antibody | |
| CPT I antibody | |
| CPT1 antibody | |
| CPT1 L antibody | |
| CPT1-L antibody | |
| Cpt1a antibody | |
| CPT1A_HUMAN antibody | |
| CPTI antibody | |
| CPTI-L antibody | |
| L CPT1 antibody | |
| liver isoform antibody |
靶标信息
Catalyzes the transfer of the acyl group of long-chain fatty acid-CoA conjugates onto carnitine, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion (PubMed:11350182, PubMed:14517221, PubMed:16651524, PubMed:9691089).
Possesses also a lysine succinyltransferase activity that can regulate enzymatic activity of substrate proteins such as ENO1 and metabolism independent of its classical carnitine O-palmitoyltransferase activity (PubMed:29425493).
Plays an important role in hepatic triglyceride metabolism (By similarity).
Plays also a role in inducible regulatory T-cell (iTreg) differentiation once activated by butyryl-CoA that antagonizes malonyl-CoA-mediated CPT1A repression (By similarity).
Sustains the IFN-I response by recruiting ZDHCC4 to palmitoylate MAVS at the mitochondria leading to MAVS stabilization and activation (PubMed:38016475).
Promotes ROS-induced oxidative stress in liver injury via modulation of NFE2L2 and NLRP3-mediated signaling pathways (By similarity).
产品来源
洱畔科技实验室
