Anti-CD3E Antibody
产品特性
| Product Cat#: | AB-06-4942 |
| Product type: | Primary antibody |
| Antigen: | CD3E |
| Immunogen: | Synthetic peptide within Human CD3E aa 158-207/207. |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:250-1:500) |
| Reactivity: | Human, Mouse, Rat |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | 1*PBS buffer (pH7.4), 0.1% BSA, 40% Glycerol, 0.05% NaN3. |
| Concentration: | 1 mg/ml |
| Purity: | Immunogen affinity purified. |
| Storage: | Aliquot and freeze at -20°C. Avoid multiple freeze/thaw cycles. |
| Conjugate: | Unconjugated |
| Alternative names: | CD3 epsilon antibody |
| CD3e antibody | |
| CD3e antigen antibody | |
| CD3e antigen epsilon polypeptide (TiT3 complex) antibody | |
| CD3E antigen epsilon polypeptide antibody | |
| CD3E antigen, epsilon subunit antibody | |
| CD3e molecule epsilon antibody | |
| CD3e molecule, epsilon (CD3 TCR complex) antibody | |
| CD3e molecule, epsilon (CD3-TCR complex) antibody | |
| CD3E_HUMAN antibody | |
| IMD18 antibody | |
| T cell antigen receptor complex epsilon subunit of T3 antibody | |
| T cell surface antigen T3/Leu 4 epsilon chain antibody | |
| T cell surface glycoprotein CD3 epsilon chain antibody | |
| T-cell surface antigen T3/Leu-4 epsilon chain antibody | |
| T-cell surface glycoprotein CD3 epsilon chain antibody | |
| T3E antibody | |
| TCRE antibody |
靶标信息
Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways (PubMed:2470098).
In addition of this role of signal transduction in T-cell activation, CD3E plays an essential role in correct T-cell development. Initiates the TCR-CD3 complex assembly by forming the two heterodimers CD3D/CD3E and CD3G/CD3E. Participates also in internalization and cell surface down-regulation of TCR-CD3 complexes via endocytosis sequences present in CD3E cytosolic region (PubMed:10384095, PubMed:26507128).
产品来源
洱畔科技实验室
