Anti-CD35 Mouse Monoclonal antibody
产品特性
| Product Cat#: | AB-06-4982 |
| Product type: | Primary antibody |
| Antigen: | CD35 |
| Immunogen: | Synthetic peptide within C-terminal human CD35. |
| Molecular weight: | Predicted band size: 224 kDa, Observed band size: ~280 kDa |
| Species immunized: | Mouse |
| Isotype: | IgG1 |
| Applications: | Western Blot (1:500-1:2000); Immunohistochemistry-Paraffin (1:1000-1:2000) |
| Reactivity: | Human |
| Clonality (clone number): | Monoclonal, A4G1 |
| Form: | Liquid |
| Buffer: | 1*PBS buffer (pH7.4), 40% glycerol, 0.05% BSA, 0.05% NaN3. |
| Concentration: | 2 mg/mL |
| Purity: | Protein G affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | C3 binding protein antibody |
| C3b/C4b receptor antibody | |
| C3BR antibody | |
| C4BR antibody | |
| CD 35 antibody | |
| CD35 antibody | |
| CD35 antigen antibody | |
| complement component (3b/4b) receptor 1 (Knops blood group) antibody | |
| complement component (3b/4b) receptor 1 including Knops blood group system antibody | |
| Complement component receptor 1 antibody | |
| Complement receptor 1 antibody | |
| Complement receptor type 1 antibody | |
| CR 1 antibody | |
| CR1 antibody | |
| CR1_HUMAN antibody | |
| KN antibody | |
| Knops blood group antigen antibody |
靶标信息
Membrane immune adherence receptor that plays a critical role in the capture and clearance of complement-opsonized pathogens by erythrocytes and monocytes/macrophages (PubMed:2963069).
Mediates the binding by these cells of particles and immune complexes that have activated complement to eliminate them from the circulation (PubMed:2963069).
Acts also in the inhibition of spontaneous complement activation by impairing the formation and function of the alternative and classical pathway C3/C5 convertases, and by serving as a cofactor for the cleavage by factor I of C3b to iC3b, C3c and C3d,g, and of C4b to C4c and C4d (PubMed:2972794, PubMed:8175757).
Also plays a role in immune regulation by contributing, upon ligand binding, to the generation of regulatory T cells from activated helper T cells (PubMed:25742728).
产品来源
洱畔科技实验室
