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Anti-CD33 antibody

产品货号 产品 品牌 单位 存货 价格 促销价 数量  
AB-06-0903
Anti-CD33 antibody
洱畔/Erpan Tech 有货

产品特性        

Product Cat#: AB-06-0903
Product type: Primary antibody
Antigen: CD33
Immunogen: Recombinant protein
Species immunized: Mouse
Isotype: IgG1
Applications: Western Blot ( 1:300-1:1000 ); Immunohistochemistry ( 1:80-1:200 ); Flow Cytometry ( 1:80-1:200 )
Reactivity: Human
Clonality (clone number): Monoclonal ( B7-C6 )
Form: Liquid
Buffer: Tris-HCl buffer ( pH7.4), 1 % BSA, 40 % glycerol, 0.05 % NaN3.
Concentration: 1 mg/ml
Purity: Protein A affinity purified
Storage: Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles.
Alternative names: CD 33 Antibody
CD33 Antibody
CD33 Antigen (gp67) Antibody
CD33 Antigen ( Antibody
CD33 Molecule Antibody
CD33_HUMAN Antibody
FLJ00391 Antibody
gp67 Antibody
My9 Antibody
Myeloid CellSurface Antigen ( CD33 Antibody
Myeloid Cell Surface Antigen ( CD33 precursor Antibody
Myeloid Differentiation Antigen ( CD33 Antibody
p67 Antibody
Sialic Acid Binding Ig Like Lectin 3 Antibody
Sialic Acid Binding Immunoglobulin Like Lectin 3 Antibody
Sialic Acid-binding Ig-like Lectin 3 Antibody
SIGLEC 3 Antibody
Siglec-3 Antibody
SIGLEC3 Antibody
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靶标信息

Sialic-acid-binding immunoglobulin-like lectin (Siglec) that plays a role in mediating cell-cell interactions and in maintaining immune cells in a resting state. Preferentially recognizes and binds alpha-2,3- and more avidly alpha-2,6-linked sialic acid-bearing glycans. Upon engagement of ligands such as C1q or syalylated glycoproteins, two immunoreceptor tyrosine-based inhibitory motifs (ITIMs) located in CD33 cytoplasmic tail are phosphorylated by Src-like kinases such as LCK. These phosphorylations provide docking sites for the recruitment and activation of protein-tyrosine phosphatases PTPN6/SHP-1 and PTPN11/SHP-2. In turn, these phosphatases regulate downstream pathways through dephosphorylation of signaling molecules. One of the repressive effect of CD33 on monocyte activation requires phosphoinositide 3-kinase/PI3K.

产品来源

洱畔科技实验室

文件下载

MSDS-AB-06-0903.pdf (下载163 )