Anti-CBX3 antibody
产品特性
| Product Cat#: | AB-06-0793 |
| Product type: | Primary antibody |
| Antigen: | CBX3 |
| Immunogen: | Purified recombinant fragment of human CBX3 expressed in E. Coli. |
| Species immunized: | Mouse |
| Isotype: | IgG1 |
| Applications: | Western Blot (1:550-1:2000); Immunohistochemistry (1:60-1:200); Flow Cytometry (1:90-1:200) |
| Reactivity: | Human |
| Clonality (clone number): | Monoclonal (D1-C4) |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 1% BSA, 40% glycerol, 0.05% NaN3. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | CBX 3 antibody |
| CBX3 antibody | |
| CBX3_HUMAN antibody | |
| Chromobox homolog 3 (HP1 gamma homolog, Drosophila) antibody | |
| Chromobox homolog 3 antibody | |
| Chromobox protein homolog 3 antibody | |
| GAMMA antibody | |
| HECH antibody | |
| Heterochromatin like protein 1 antibody | |
| Heterochromatin protein 1 homolog gamma antibody | |
| Heterochromatin protein HP1 gamma antibody | |
| HP1 gamma antibody | |
| HP1 gamma homolog antibody | |
| HP1Hs gamma antibody | |
| Modifier 2 protein antibody |
靶标信息
Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at ‘Lys-9’, leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 ‘Lys-9’ trimethylation, mediates the recruitment of the methyltransferases SUV39H1 and/or SUV39H2 by the PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1. Mediates the recruitement of NIPBL to sites of DNA damage at double-strand breaks (DSBs) (PubMed:28167679).
产品来源
洱畔科技实验室
