Anti-CBX2 antibody
产品特性
| Product Cat#: | AB-06-0792 |
| Product type: | Primary antibody |
| Antigen: | CBX2 |
| Immunogen: | Purified recombinant fragment of human CBX2 expressed in E. Coli. |
| Species immunized: | Mouse |
| Isotype: | IgG1 |
| Applications: | Western Blot (1:550-1:2000); Immunohistochemistry (1:190-1:500); Immunocytochemistry (1:190-1:1000); Flow Cytometry (1:60-1:200) |
| Reactivity: | Mouse, Human |
| Clonality (clone number): | Monoclonal (C11-B10) |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 1% BSA, 40% glycerol, 0.05% NaN3. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | Cbx 2 antibody |
| CBX2 antibody | |
| CBX2_HUMAN antibody | |
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靶标信息
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (PubMed:21282530). PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A ‘Lys-119’, rendering chromatin heritably changed in its expressibility (PubMed:21282530). Binds to histone H3 trimethylated at ‘Lys-9’ (H3K9me3) or at ‘Lys-27’ (H3K27me3) (By similarity). Plays a role in the lineage differentiation of the germ layers in embryonic development (By similarity). Involved in sexual development, acting as activator of NR5A1 expression (PubMed:19361780).
产品来源
洱畔科技实验室