Anti-Caspase-3 p12 Recombinant Rabbit Monoclonal Antibody
产品特性
| Product Cat#: | AB-06-6152 |
| Product type: | Primary antibody |
| Antigen: | Caspase-3 p12 |
| Immunogen: | Recombinant protein within Human Caspase-3 p12 aa 128-277. |
| Molecular weight: | Predicted band size: 32/12 kDa |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:500-1:2,000); Immunohistochemistry-Paraffin (1:200-1:1,000) |
| Reactivity: | Human, Mouse, Rat |
| Clonality (clone number): | Monoclonal, JE07-51 |
| Form: | Liquid |
| Buffer: | 1*TBS buffer (pH7.4), 40% glycerol, 0.05% BSA, 0.05% NaN3. |
| Concentration: | 1 mg/mL |
| Purity: | Protein A affinity purified. |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | Caspase3 |
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| CASP3_HUMAN antibody | |
| Casp3a antibody | |
| Caspase 3 antibody | |
| Caspase 3, apoptosis-related cysteine peptidase antibody | |
| Caspase 3, apoptosis-related cysteine protease antibody | |
| Caspase 3, apoptosis-related cysteine protease a antibody | |
| Caspase-3 subunit p12 antibody | |
| Caspase3 antibody | |
| CC3 antibody | |
| CPP 32 antibody | |
| CPP-32 antibody | |
| CPP32 antibody | |
| CPP32B antibody | |
| Cysteine protease CPP32 antibody | |
| EC 3.4.22.56 antibody | |
| ICE3 antibody | |
| LICE antibody | |
| mldy antibody | |
| OTTHUMP00000165052 antibody | |
| OTTHUMP00000165053 antibody | |
| OTTHUMP00000165054 antibody | |
| PARP cleavage protease antibody | |
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| SCA 1 antibody | |
| SCA-1 antibody | |
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靶标信息
Thiol protease that acts as a major effector caspase involved in the execution phase of apoptosis (PubMed:18723680, PubMed:20566630, PubMed:23650375, PubMed:35338844, PubMed:35446120, PubMed:7596430).
Following cleavage and activation by initiator caspases (CASP8, CASP9 and/or CASP10), mediates execution of apoptosis by catalyzing cleavage of many proteins (PubMed:18723680, PubMed:20566630, PubMed:23650375, PubMed:7596430).
At the onset of apoptosis, it proteolytically cleaves poly(ADP-ribose) polymerase PARP1 at a ‘216-Asp-|-Gly-217’ bond (PubMed:10497198, PubMed:16374543, PubMed:7596430, PubMed:7774019).
Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain (By similarity).
Cleaves and activates caspase-6, -7 and -9 (CASP6, CASP7 and CASP9, respectively) (PubMed:7596430).
Cleaves and inactivates interleukin-18 (IL18) (PubMed:37993714, PubMed:9334240).
Involved in the cleavage of huntingtin (PubMed:8696339).
Triggers cell adhesion in sympathetic neurons through RET cleavage (PubMed:21357690).
Cleaves and inhibits serine/threonine-protein kinase AKT1 in response to oxidative stress (PubMed:23152800).
Acts as an inhibitor of type I interferon production during virus-induced apoptosis by mediating cleavage of antiviral proteins CGAS, IRF3 and MAVS, thereby preventing cytokine overproduction (PubMed:30878284).
Also involved in pyroptosis by mediating cleavage and activation of gasdermin-E (GSDME) (PubMed:35338844, PubMed:35446120).
Cleaves XRCC4 and phospholipid scramblase proteins XKR4, XKR8 and XKR9, leading to promote phosphatidylserine exposure on apoptotic cell surface (PubMed:23845944, PubMed:33725486).
Cleaves BIRC6 following inhibition of BIRC6-caspase binding by DIABLO/SMAC (PubMed:36758104, PubMed:36758106).
产品来源
洱畔科技实验室
