Anti-BLNK antibody
产品特性
| Product type: | Primary antibody |
| Antigen: | BLNK |
| Immunogen: | Purified recombinant fragment of human BLNK expressed in E. Coli. |
| Species immunized: | Mouse |
| Isotype: | IgG1 |
| Applications: | Western Blot (1:400-1:2000); Immunohistochemistry (1:100-1:500); Immunocytochemistry (1:100-1:200); Flow Cytometry (1:100-1:200) |
| Reactivity: | Mouse, Human |
| Clonality (clone number): | Monoclonal, G1-F9 |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 1% BSA, 40% glycerol, 0.05% NaN3. |
| Concentration: | 1mg/ml |
| Purity: | Protein A/G affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | AGM4 antibody |
| B cell adapter containing SH2 domain protein antibody | |
| B cell adapter containing Src homology 2 domain protein antibody | |
| B cell adaptor containing SH2 domain antibody | |
| B cell linker antibody | |
| B cell linker protein antibody | |
| B cell-specific adaptor protein antibody | |
| B-cell activation antibody | |
| B-cell adapter containing a SH2 domain protein antibody | |
| B-cell adapter containing a Src homology 2 domain protein antibody | |
| B-cell linker protein antibody | |
| BASH antibody | |
| Bca antibody | |
| BLNK antibody | |
| BLNK s antibody | |
| BLNK_HUMAN antibody | |
| Cytoplasmic adapter protein antibody | |
| Ly 57 antibody | |
| Ly57 antibody | |
| Lymphocyte antigen 57 antibody | |
| Lyw 57 antibody | |
| Lyw57 antibody | |
| MGC111051 antibody | |
| SH2 domain-containing leukocyte protein, 65-KD antibody | |
| SLP 65 antibody | |
| SLP-65 antibody | |
| SLP65 antibody | |
| Src homology [SH2] domain-containing leukocyte protein of 65 kD antibody | |
| Src homology 2 domain containing leukocyte protein of 65 kDa antibody | |
| Src homology 2 domain-containing leukocyte protein of 65 kDa antibody |
靶标信息
Functions as a central linker protein, downstream of the B-cell receptor (BCR), bridging the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK. Modulates AP1 activation. Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR-mediated PLCG1 and PLCG2 activation and Ca2+ mobilization and is required for trafficking of the BCR to late endosomes. However, does not seem to be required for pre-BCR-mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signaling. May be required for the RAC1-JNK pathway. Plays a critical role in orchestrating the pro-B cell to pre-B cell transition. May play an important role in BCR-induced B-cell apoptosis.
产品来源
洱畔科技实验室