Anti-BAG1 antibody
产品特性
| Product Cat#: | AB-06-0451 |
| Product type: | Primary antibody |
| Antigen: | BAG1 |
| Immunogen: | Purified recombinant fragment of human BAG1 expressed in E. Coli. |
| Species immunized: | Mouse |
| Isotype: | IgG1 |
| Applications: | Western Blot (1:400-1:2000); Flow Cytometry (1:50-1:100) |
| Reactivity: | Human |
| Clonality (clone number): | Monoclonal, F11-A7 |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 1% BSA, 40% glycerol, 0.05% NaN3. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A/G affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | Bag 1 antibody |
| BAG family molecular chaperone regulator 1 antibody | |
| BAG-1 antibody | |
| BAG1 antibody | |
| BAG1_HUMAN antibody | |
| BCL 2 Associated Athanogene 1 antibody | |
| BCL 2 associated athanogene antibody | |
| BCL 2 binding athanogene 1 antibody | |
| Bcl-2-associated athanogene 1 antibody | |
| BCL2 associated athanogene 1 antibody | |
| BCL2 associated athanogene antibody | |
| Glucocorticoid receptor-associated protein RAP46 antibody | |
| HAP1 antibody | |
| Haptoglobin antibody | |
| RAP 46 antibody | |
| RAP46 antibody |
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靶标信息
Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleotide release is mediated via its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70 where as the substrate release is mediated via its binding to the substrate-binding domain (SBD) of HSPA8/HSC70 (PubMed:27474739, PubMed:9873016, PubMed:24318877). Inhibits the pro-apoptotic function of PPP1R15A, and has anti-apoptotic activity (PubMed:12724406). Markedly increases the anti-cell death function of BCL2 induced by various stimuli (PubMed:9305631).
产品来源
洱畔科技实验室