Anti-ARIH2 antibody
产品特性
| Product Cat#: | AB-06-0370 |
| Product type: | Primary antibody |
| Antigen: | ARIH2 |
| Immunogen: | KLH conjugated synthetic peptide derived from human ARIH2 41-140/493 |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:400-1:2000) |
| Reactivity: | Human, Mouse, Rat, Chicken, Pig, Cow, Rabbit |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| Concentration: | 1mg/ml |
| Purity: | Protein A/G affinity purified/Antigen affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | All Trans Retinoic Acid Inducible RING Finger |
| Ari 2 | |
| Ari-2 | |
| ARI2 | |
| ARI2_HUMAN | |
| Ariadne 2 | |
| Ariadne 2 Protein Homolog | |
| Ariadne Homolog 2 (Drosophila) | |
| Ariadne Homolog 2 | |
| ARIH 2 | |
| Arih2 | |
| E3 Ubiquitin Protein Ligase ARIH2 | |
| E3 Ubiquitin-Protein Ligase ARIH2 | |
| HT005 | |
| Protein Ariadne 2 Homolog | |
| Protein Ariadne-2 Homolog | |
| Triad 1 | |
| TRIAD1 | |
| Triad1 Protein |
靶标信息
E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 UBE2L3 (PubMed:16118314, PubMed:17646546, PubMed:19340006, PubMed:24076655). Acts as an atypical E3 ubiquitin-protein ligase by working together with cullin-5-RING ubiquitin ligase complex (ECS complex, also named CRL5 complex) and initiating ubiquitination of ECS substrates: associates with ECS complex and specifically mediates addition of the first ubiquitin on ECS targets (By similarity). The initial ubiquitin is then elongated (By similarity). E3 ubiquitin-protein ligase activity is activated upon binding to neddylated form of the ECS complex (PubMed:24076655). Mediates ‘Lys-6’, ‘Lys-48’-and ‘Lys-63’-linked polyubiquitination (PubMed:16118314, PubMed:17646546, PubMed:19340006). May play a role in myelopoiesis (PubMed:19340006).
产品来源
洱畔科技实验室
