Anti-Aly Recombinant Rabbit Monoclonal Antibody
产品特性
| Product Cat#: | AB-06-5109 |
| Product type: | Primary antibody |
| Antigen: | Aly |
| Immunogen: | Synthetic peptide within Human Aly aa 208-257. |
| Molecular weight: | Predicted band size: 27 kDa; Observed band size: 27 kDa |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:500-1:2000); Immunohistochemistry-Paraffin (1:500-1:2000); Immunocytochemistry (1:200); Flow Cytometry (1:500) |
| Reactivity: | Human, Mouse, Rat |
| Clonality (clone number): | Monoclonal, JE36-45 |
| Form: | Liquid |
| Buffer: | 1*Tris-HCl buffer (pH7.4), 40% glycerol, 0.1% BSA, 0.05% NaN3. |
| Concentration: | 1 μg/μL |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | Ally of AML-1 and LEF-1 antibody |
| Ally of AML1 and LEF1 antibody | |
| ALY antibody | |
| ALY/REF antibody | |
| Aly/REF export factor antibody | |
| BEF antibody | |
| bZIP enhancing factor antibody | |
| bZIP-enhancing factor BEF antibody | |
| REF antibody | |
| THO complex 4 antibody | |
| THO complex subunit 4 antibody | |
| Tho4 antibody | |
| thoc4 antibody | |
| THOC4_HUMAN antibody | |
| Transcriptional coactivator Aly/REF antibody | |
| Transcriptional coactivator antibody |
靶标信息
Export adapter involved in nuclear export of spliced and unspliced mRNA. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NFX1 pathway) (PubMed:11675789, PubMed:11707413, PubMed:11979277, PubMed:15833825, PubMed:15998806, PubMed:17190602, PubMed:18364396, PubMed:22144908, PubMed:22893130, PubMed:23222130, PubMed:25662211).
Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA (PubMed:15833825, PubMed:15998806, PubMed:17190602).
TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5′ end of the mRNA where it functions in mRNA export to the cytoplasm (PubMed:15833825, PubMed:15998806, PubMed:17190602).
TREX recruitment occurs via an interaction between ALYREF/THOC4 and the cap-binding protein NCBP1 (PubMed:15833825, PubMed:15998806, PubMed:17190602).
The TREX complex is essential for the export of Kaposi’s sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production; ALYREF/THOC4 mediates the recruitment of the TREX complex to the intronless viral mRNA (PubMed:18974867).
Required for TREX complex assembly and for linking DDX39B to the cap-binding complex (CBC) (PubMed:15998806, PubMed:17984224).
In conjunction with THOC5 functions in NXF1-NXT1 mediated nuclear export of HSP70 mRNA; both proteins enhance the RNA binding activity of NXF1 and are required for NXF1 localization to the nuclear rim (PubMed:19165146).
Involved in the nuclear export of intronless mRNA; proposed to be recruited to intronless mRNA by ATP-bound DDX39B. Involved in transcription elongation and genome stability (PubMed:12438613, PubMed:17984224).
Involved in mRNA export of C5-methylcytosine (m5C)-containing mRNAs: specifically recognizes and binds m5C mRNAs and mediates their nucleo-cytoplasmic shuttling (PubMed:28418038).
产品来源
洱畔科技实验室
