Anti-AKR1B1 Rabbit Polyclonal Antibody
产品特性
| Product Cat#: | AB-06-5098 |
| Product type: | Primary antibody |
| Antigen: | AKR1B1 |
| Immunogen: | Synthetic peptide within human AKR1B1 aa 1-50. |
| Molecular weight: | Predicted band size: 36 kDa, Observed band size: 36 kDa |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:500-1:2000); Immunohistochemistry-Paraffin (1:100-1:500) |
| Reactivity: | Human, Mouse, Rat |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | 1*Tris-HCl buffer (pH7.4), 40% glycerol, 0.05% BSA, 0.05% NaN3. |
| Concentration: | 1 mg/mL |
| Purity: | Immunogen affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | ADR antibody |
| AKR1B 1 antibody | |
| Akr1b1 antibody | |
| Aldehyde reductase 1 antibody | |
| Aldehyde reductase antibody | |
| Aldo keto reductase family 1, member B1 antibody | |
| Aldo-keto reductase family 1 member B1 antibody | |
| aldo-keto reductase family 1, member B1 (aldose reductase) antibody | |
| Aldose reductase antibody | |
| aldr 1 antibody | |
| ALDR_HUMAN antibody | |
| aldr1 antibody | |
| ALR2 antibody | |
| AR antibody | |
| Lii5 2 CTCL tumor antigen antibody | |
| Low Km aldose reductase antibody | |
| MGC1804 antibody |
靶标信息
Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosacharides, bile acids and xenobiotics substrates. Key enzyme in the polyol pathway, catalyzes reduction of glucose to sorbitol during hyperglycemia (PubMed:1936586).
Reduces steroids and their derivatives and prostaglandins. Displays low enzymatic activity toward all-trans-retinal, 9-cis-retinal, and 13-cis-retinal (PubMed:12732097, PubMed:19010934, PubMed:8343525).
Catalyzes the reduction of diverse phospholipid aldehydes such as 1-palmitoyl-2-(5-oxovaleroyl)-sn -glycero-3-phosphoethanolamin (POVPC) and related phospholipid aldehydes that are generated from the oxydation of phosphotidylcholine and phosphatdyleethanolamides (PubMed:17381426).
Plays a role in detoxifying dietary and lipid-derived unsaturated carbonyls, such as crotonaldehyde, 4-hydroxynonenal, trans-2-hexenal, trans-2,4-hexadienal and their glutathione-conjugates carbonyls (GS-carbonyls) (PubMed:21329684).
产品来源
洱畔科技实验室
