Anti-AEBP1 Rabbit Polyclonal antibody
产品特性
| Product Cat#: | AB-06-5088 |
| Product type: | Primary antibody |
| Antigen: | AEBP1 |
| Immunogen: | Synthetic peptide within human AEBP1 aa 780-810. |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:500-1:2000) |
| Reactivity: | Human, Mouse, Rat |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | 1*PBS buffer (pH7.4), 50% glycerol, 0.02% NaN3. |
| Concentration: | 1 mg/mL |
| Purity: | Immunogen affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | ACLP antibody |
| adipocyte enhancer binding protein 1 antibody | |
| AE-binding protein 1 antibody | |
| aortic carboxypeptidase-like protein antibody |
靶标信息
Plays an important role in controlling cell cycle progression and DNA damage-induced G2 arrest (PubMed:9106657).
Involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage. Also involved in p53-independent DNA damage-induced G2 arrest mediated by CREB3L1 in astrocytes and osteoblasts (By similarity).
Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex. Inhibits DNA synthesis by DNA polymerase delta by competing with POLD3 for PCNA binding (PubMed:11595739).
产品来源
洱畔科技实验室
