靶标信息
Cell surface proteoglycan (PubMed:14610063).
Negatively regulates the hedgehog signaling pathway when attached via the GPI-anchor to the cell surface by competing with the hedgehog receptor PTC1 for binding to hedgehog proteins (By similarity).
Binding to the hedgehog protein SHH triggers internalization of the complex by endocytosis and its subsequent lysosomal degradation (By similarity).
Positively regulates the canonical Wnt signaling pathway by binding to the Wnt receptor Frizzled and stimulating the binding of the Frizzled receptor to Wnt ligands (PubMed:16227623, PubMed:24496449).
Positively regulates the non-canonical Wnt signaling pathway (By similarity).
Binds to CD81 which decreases the availability of free CD81 for binding to the transcriptional repressor HHEX, resulting in nuclear translocation of HHEX and transcriptional repression (By similarity).
Inhibits the dipeptidyl peptidase activity of DPP4 (PubMed:17549790).
Plays a role in limb patterning and skeletal development by controlling the cellular response to BMP4 (By similarity).
Modulates the effects of growth factors BMP2, BMP7 and FGF7 on renal branching morphogenesis (By similarity).
Required for coronary vascular development (By similarity).
Plays a role in regulating cell movements during gastrulation (By similarity).
相关文献
1、Jiao J, Jiao D, Yang F, Zhang J, Li Y, Han D, Zhang K, Wang Y, Zhang R, Yang AG, Wang A, Wen W, Qin W. Galectin-9 expression predicts poor prognosis in hepatitis B virus-associated hepatocellular carcinoma. Aging (Albany NY). 2022 Feb 24;14(4):1879-1890. doi: 10.18632/aging.203909. Epub 2022 Feb 24. PMID: 35202002; PMCID: PMC8908941.
2、Jiang Z, Cheng L, Wu Z, Zhou L, Wang H, Hong Q, Wu Q, Long Y, Huang Y, Xu G, Yao Y, Tang Z, Zhang Z, Yang L, Luo W, Yang J, Gong L, Liu P, Chen X, Cui S, Zhang Q, Li Y, Li P. Transforming primary human hepatocytes into hepatocellular carcinoma with genetically defined factors. EMBO Rep. 2022 Jun 7;23(6):e54275. doi: 10.15252/embr.202154275. Epub 2022 Apr 19. PMID: 35437924; PMCID: PMC9171684.
3、Sahu B, Pihlajamaa P, Zhang K, Palin K, Ahonen S, Cervera A, Ristimäki A, Aaltonen LA, Hautaniemi S, Taipale J. Human cell transformation by combined lineage conversion and oncogene expression. Oncogene. 2021 Sep;40(36):5533-5547. doi: 10.1038/s41388-021-01940-0. Epub 2021 Jul 23. PMID: 34302118; PMCID: PMC8429043.
4、Feng S, Meng X, Li Z, Chang TS, Wu X, Zhou J, Joshi B, Choi EY, Zhao L, Zhu J, Wang TD. Multi-Modal Imaging Probe for Glypican-3 Overexpressed in Orthotopic Hepatocellular Carcinoma. J Med Chem. 2021 Nov 11;64(21):15639-15650. doi: 10.1021/acs.jmedchem.1c00697. Epub 2021 Sep 30. PMID: 34590489; PMCID: PMC9007039.
