重组Anti-C3抗体[EPR19394] (ab200999)
产品特性
| Product Cat#: | ab200999 |
| Product type: | Primary antibody |
| Antigen: | C3 |
| Immunogen: | Synthetic peptide. |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | IHC-P, WB |
| Reactivity: | Mouse, Rat, Human |
| Clonality (clone number): | Monoclonal, EPR19394 |
| Form: | Liquid |
| Buffer: | pH: 7.20 |
| Preservative: 0.01% Sodium azide | |
| Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA | |
| Concentration: | - mg/ml |
| Purity: | Protein A purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | Acylation stimulating protein cleavage product antibody |
| AHUS5 antibody | |
| ARMD9 antibody | |
| ASP antibody | |
| C3 and PZP like alpha 2 macroglobulin domain containing protein 1 antibody | |
| C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1 antibody | |
| C3 antibody | |
| c3 complement antibody | |
| C3adesArg antibody | |
| CO3_HUMAN antibody | |
| Complement C3 alpha chain antibody | |
| Complement C3 antibody | |
| Complement C3b alpha' chain antibody | |
| Complement C3c alpha' chain fragment 1 antibody | |
| Complement C3c alpha' chain fragment 2 antibody | |
| Complement C3c alpha" chain fragment 2 antibody | |
| Complement C3d fragment antibody | |
| Complement C3dg fragment antibody | |
| Complement C3f fragment antibody | |
| Complement C3g fragment antibody | |
| Complement component 3 antibody | |
| Complement factor 3 antibody | |
| CPAMD1 antibody | |
| HEL S 62p antibody | |
| omplement C3 beta chain antibody |
靶标信息
C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates.
Derived from proteolytic degradation of complement C3, C3a anaphylatoxin is a mediator of local inflammatory process. In chronic inflammation, acts as a chemoattractant for neutrophils (By similarity).
It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes.
相关文献
1、Xie T, Shuang L, Liu G, Zhao S, Yuan Z, Cai H, Jiang L, Huang Z. Insight into the Neuroprotective Effect of Genistein-3′-Sodium Sulfonate Against Neonatal Hypoxic-Ischaemic Brain Injury in Rats by Bioinformatics. Mol Neurobiol. 2023 Feb;60(2):807-819. doi: 10.1007/s12035-022-03123-8. Epub 2022 Nov 12. PMID: 36370154; PMCID: PMC9849302.
2、Choi YJ, Kim JE, Lee SJ, Gong JE, Jin YJ, Lee H, Hwang DY. Promotion of the inflammatory response in mid colon of complement component 3 knockout mice. Sci Rep. 2022 Feb 1;12(1):1700. doi: 10.1038/s41598-022-05708-8. PMID: 35105928; PMCID: PMC8807838.
3、Meng S, Wen D, Xiao J, Zhang Q, Fang W, Xue X, Hu T, Xia X. Age of Rats Affects the Degree of Retinal Neuroinflammatory Response Induced by High Acute Intraocular Pressure. Dis Markers. 2022 Jan 29;2022:9404977. doi: 10.1155/2022/9404977. PMID: 35132339; PMCID: PMC8817888.