产品特性

Product Cat#:	AB-06-3374
Product type:	Primary antibody
Antigen:	PCAF
Immunogen:	Recombinant protein
Species immunized:	Rabbit
Isotype:	IgG
Applications:	Western Blot (1:400-1:2000); Immunoprecipitation (1:10-1:40); Flow Cytometry (1:40-1:100)
Reactivity:	Human, Mouse, Rat
Clonality (clone number):	Monoclonal (JU88-63)
Form:	Liquid
Buffer:	1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration:	1 mg/ml
Purity:	Protein A affinity purified
Storage:	Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles.
Alternative names:	CAF antibody
	CREBBP associated factor antibody
	GCN5 antibody
	GCN5L antibody
	GCN5L1 antibody
	Histone acetylase PCAF antibody
	Histone acetyltransferase KAT2B antibody
	Histone acetyltransferase PCAF antibody
	K(lysine) acetyltransferase 2B antibody
	KAT2B antibody
	KAT2B_HUMAN antibody
	Lysine acetyltransferase 2B antibody
	P antibody
	P/CAF antibody
	p300/CBP associated factor antibody
	P300/CBP-associated factor antibody
	Pcaf antibody

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靶标信息

Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Has significant histone acetyltransferase activity with core histones (H3 and H4), and also with nucleosome core particles. Also acetylates non-histone proteins, such as ACLY, PLK4 and TBX5. Inhibits cell-cycle progression and counteracts the mitogenic activity of the adenoviral oncoprotein E1A. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers. Involved in heart and limb development by mediating acetylation of TBX5, acetylation regulating nucleocytoplasmic shuttling of TBX5 (PubMed:29174768). Acts as a negative regulator of centrosome amplification by mediating acetylation of PLK4 (PubMed:27796307). Also acetylates spermidine (PubMed:27389534).

产品来源

洱畔科技实验室

文件下载

Material-Safety-Data-Sheet.pdf (下载47039)