Anti-C17ORF53 antibody
产品特性
| Product type: | Primary antibody |
| Antigen: | C17ORF53 |
| Immunogen: | Purified recombinant fragment of human C17ORF53 expressed in E. Coli. |
| Species immunized: | Rabbit |
| Isotype: | IgG2b |
| Applications: | Western Blot (1:500-1:1000); Immunocytochemistry (1:100-1:200); Flow Cytometry (1:50-1:200) |
| Reactivity: | Human |
| Clonality (clone number): | Monoclonal, A9-A3 |
| Form: | Liquid |
| Buffer: | 1*TBS (pH7.4), 1%BSA, 0.03% Proclin300 and 50% Glycerol. |
| Concentration: | 1mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | C17orf53 antibody |
| Chromosome 17 open reading frame 53 antibody | |
| CQ053_HUMAN antibody | |
| FLJ11594 antibody | |
| Hypothetical protein LOC78995 antibody | |
| MGC3130 antibody | |
| Uncharacterized protein C17orf53 antibody |
靶标信息
C17orf53 (chromosome 17 open reading frame 53) is a 647 amino acid protein that is encoded by a gene mapping to human chromosome 17. Chromosome 17 makes up over 2.5% of the human genome with about 81 million bases encoding over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes. Chromosome 17 is also linked to neurofibromatosis, a condition characterized by neural and epidermal lesions, and dysregulated Schwann cell growth. Alexander disease, Birt-Hogg-Dube syndrome and Canavan disease are also associated with chromosome 17.
产品来源
洱畔科技实验室