Anti-BMAL1 antibody
产品特性
| Product type: | Primary antibody |
| Antigen: | BMAL1 |
| Immunogen: | Recombinant protein |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:1000-1:2000); Immunocytochemistry/Immunofluorescence (1:100-1:200) |
| Reactivity: | Mouse, Rat and Human |
| Clonality (clone number): | Monoclonal, JM17-34 |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 1% BSA, 40% glycerol, 0.05% NaN3. |
| Concentration: | 1mg/ml |
| Purity: | Protein A/G affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | ARNT like protein 1 brain and muscle antibody |
| Arntl antibody | |
| Aryl hydrocarbon receptor nuclear translocator like antibody | |
| Aryl hydrocarbon receptor nuclear translocator like protein 1 antibody | |
| Aryl hydrocarbon receptor nuclear translocator-like protein 1 antibody | |
| Basic helix loop helix PAS orphan MOP3 antibody | |
| Basic helix loop helix PAS protein MOP3 antibody | |
| Basic-helix-loop-helix-PAS protein MOP3 antibody | |
| bHLH PAS protein JAP3 antibody | |
| bHLH-PAS protein JAP3 antibody | |
| bHLHe5 antibody | |
| BMAL 1 antibody | |
| BMAL1_HUMAN antibody | |
| BMAL1c antibody | |
| Brain and muscle ARNT like 1 antibody | |
| Brain and muscle ARNT-like 1 antibody | |
| CG8727 PA antibody | |
| Class E basic helix-loop-helix protein 5 antibody | |
| Cycle antibody | |
| JAP 3 antibody | |
| JAP3 antibody | |
| Member of PAS protein 3 antibody | |
| Member of PAS superfamily 3 antibody | |
| MGC47515 antibody | |
| MOP 3 antibody | |
| MOP3 antibody | |
| PAS domain-containing protein 3 antibody | |
| PASD 3 antibody | |
| PASD3 antibody | |
| TIC antibody |
靶标信息
BMAL1, ARNTL2 (aryl hydrocarbon receptor nuclear translocator-like 2) is a basic Helix-Loop-Helix-Per-Arnt-Sim (bHLH-PAS) transcription factor. ARNTL2-CLOCK heterodimers activate E-box element (3′-CACGTG-5′) transcription. Also, in umbilical vein endothelial cells, ARNTL2 activates SERPINE1 through E-box sites. This transactivation is inhibited by PER2 and CRY1. The NPAS2-ARNTL/BMAL1 heterodimer positively regulates the expression of MAOA, F7 and LDHA and modulates the circadian rhythm of daytime contrast sensitivity by regulating the rhythmic expression of adenylate cyclase type 1 (ADCY1) in the retina. The CLOCK-ARNTL/BMAL1 heterodimer also recognizes the non-canonical E-box motifs 5′-AACGTGA-3′ and 5′-CATGTGA-3′. Essential for the rhythmic interaction of CLOCK with ASS1 and plays a critical role in positively regulating CLOCK-mediated acetylation of ASS1.
产品来源
洱畔科技实验室
