购物车里没有产品

Anti-Autoimmune Regulator antibody

产品货号 产品 品牌 单位 存货 价格 促销价 数量  
AB-06-0428
Anti-Autoimmune Regulator antibody
洱畔/Erpan Tech 有货

产品特性        

Product Cat#: AB-06-0428
Product type: Primary antibody
Antigen: Autoimmune Regulator
Immunogen: This antibody is produced by immunizing rabbits with a synthetic peptide (KLH-coupled) corresponding to AIRE.
Species immunized: Rabbit
Isotype: IgG
Applications: Western Blot (1:500-1:1000); Immunohistochemistry (1:100); Flow Cytometry (1:100-1:200)
Reactivity: Human
Clonality (clone number): Polyclonal
Form: Liquid
Buffer: Tris-HCl buffer (pH7.4), 1% BSA, 40% glycerol, 0.05% NaN3.
Concentration: 1 mg/ml
Purity: Immunogen affinity purified
Storage: Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles.
Alternative names: AIRE antibody
AIRE_HUMAN antibody
AIRE1 antibody
APECED antibody
APECED protein antibody
APS1 antibody
APSI antibody
Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein antibody
Autoimmune regulator antibody
Autoimmune regulator protein antibody
展开

靶标信息

Transcription factor playing an essential role to promote self-tolerance in the thymus by regulating the expression of a wide array of self-antigens that have the commonality of being tissue-restricted in their expression pattern in the periphery, called tissue restricted antigens (TRA) (Probable). Binds to G-doublets in an A/T-rich environment; the preferred motif is a tandem repeat of 5′-. ATTGGTTA-3′ combined with a 5′-TTATTA-3′ box. Binds to nucleosomes (By similarity). Binds to chromatin and interacts selectively with histone H3 that is not methylated at ‘Lys-4’, not phosphorylated at ‘Thr-3’ and not methylated at ‘Arg-2’. Functions as a sensor of histone H3 modifications that are important for the epigenetic regulation of gene expression. Mainly expressed by medullary thymic epithelial cells (mTECs), induces the expression of thousands of tissue-restricted proteins, which are presented on major histocompatibility complex class I (MHC-I) and MHC-II molecules to developing T-cells percolating through the thymic medulla (By similarity). Also induces self-tolerance through other mechanisms such as the regulation of the mTEC differentiation program (PubMed:19015306). Controls the medullary accumulation of thymic dendritic cells and the development of regulatory T-cell through the regulation of XCL1 expression (PubMed:21300913). Regulates the production of CCR4 and CCR7 ligands in medullary thymic epithelial cells and alters the coordinated maturation and migration of thymocytes (PubMed:19923453). In thimic B-cells, allows the presentation of licensing-dependent endogenous self-anitgen for negative selection (PubMed:26070482). In secondary lymphoid organs, induces functional inactivation of CD4+ T-cells. Expressed by a distinct bone marrow-derived population, induces self-tolerance through a mechanism that does not require regulatory T-cells and is resitant to innate inflammatory stimuli (PubMed:23993652).

产品来源

洱畔科技实验室

文件下载

MSDS-AB-06-0428.pdf (下载62 )