产品特性

Product type:	Primary antibody
Antigen:	ERN1
Immunogen:	Purified recombinant fragment of human ERN1 expressed in E. Coli.
Species immunized:	Mouse
Isotype:	IgG1
Applications:	Western Blot (1:200-1:2000);Immunohistochemistry (1:50-1:200)
Reactivity:	Human
Clonality (clone number):	Monoclonal（C9-F2）
Form:	Liquid
Buffer:	1*TBS (pH7.4), 1%BSA, Preservative: 0.05%
Concentration:	1mg/ml
Purity:	ProA affinity purified
Storage:	Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles.
Alternative names:	Endoplasmic reticulum (ER) to nucleus signalling 1 antibody
	Endoplasmic reticulum to nucleus signaling 1 antibody
	Endoplasmic reticulum-to-nucleus signaling 1 antibody
	Endoribonuclease antibody
	ER to nucleus signaling 1 antibody
	ERN 1 antibody
	Ern1 antibody
	ERN1_HUMAN antibody
	hIRE 1p antibody
	hIRE1p antibody
	Inositol requiring 1 antibody
	Inositol requiring 1, S. cerevisiae, homolog of antibody
	Inositol requiring enzyme 1, S. cerevisiae, homolog of antibody
	Inositol requiring protein 1 antibody
	inositol-requiring enzyme 1 antibody
	Inositol-requiring protein 1 antibody
	IRE 1 antibody
	IRE 1a antibody
	IRE 1P antibody
	Ire1 alpha antibody
	Ire1-alpha antibody
	IRE1a antibody
	Ire1alpha antibody
	IRE1P antibody
	MGC163277 antibody
	MGC163279 antibody
	Protein kinase/endoribonuclease antibody
	RGD1559716 antibody
	Serine/threonine protein kinase/endoribonuclease IRE1 antibody

展开

靶标信息

Serine/threonine-protein kinase and endoribonuclease that acts as a key sensor for the endoplasmic reticulum unfolded protein response (UPR). In unstressed cells, the endoplasmic reticulum luminal domain is maintained in its inactive monomeric state by binding to the endoplasmic reticulum chaperone HSPA5/BiP. Accumulation of misfolded protein in the endoplasmic reticulum causes release of HSPA5/BiP, allowing the luminal domain to homodimerize, promoting autophosphorylation of the kinase domain and subsequent activation of the endoribonuclease activity

产品来源

洱泮科技实验室