Anti-Epac1 antibody
产品特性
| Product cat: | AB-06-1561 |
| Product type: | Primary antibody |
| Antigen: | Epac1 |
| Immunogen: | Amino acids 1-70 of Epac of human origin |
| Species immunized: | Mouse |
| Isotype: | IgG2a |
| Applications: | Western Blot (1:90-1:1000); Immunohistochemistry (1:60-1:500); Immunofluorescence (1:40-1:500); Immunoprecipitation (1-3 μg per 100-500 μg of total protein(1 ml of cell lysate)) |
| Reactivity: | Rat, Human, Hamster |
| Clonality (clone number): | Monoclonal (4G3) |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 1% BSA, 40% glycerol, 0.05% NaN3. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | bcm910 antibody |
| CAMP GEFI antibody | |
| cAMP regulated guanine nucleotide exchange factor I antibody | |
| CAMPGEFI antibody | |
| CGEF 1 antibody | |
| CGEF1 antibody | |
| EPA1 antibody | |
| Epac 1 antibody | |
| EPAC antibody | |
| EPAC1 antibody | |
| Exchange factor directly activated by cAMP 1 antibody | |
| Exchange protein directly activated by cAMP 1 antibody | |
| MGC21410 antibody | |
| RAP guanine nucleotide exchange factor antibody | |
| Rap guanine nucleotide exchange factor (GEF) 3 antibody | |
| RAP guanine nucleotide exchange factor 3 antibody | |
| Rap1 guanine nucleotide exchange factor directly activated by cAMP antibody |
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靶标信息
Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is activated by binding cAMP. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which it activates the PI3K gamma complex and which is involved in angiogenesis. Plays a role in the modulation of the cAMP-induced dynamic control of endothelial barrier function through a pathway that is independent on Rho-mediated signaling. Required for the actin rearrangement at cell-cell junctions, such as stress fibers and junctional actin.
产品来源
洱畔科技实验室
