购物车里没有产品

Anti-Smad3 antibody

产品货号 产品 品牌 单位 存货 价格 促销价 数量  
AB-06-4116
Anti-Smad3 antibody
洱畔/Erpan Tech 有货

产品特性        

Product Cat#: AB-06-4116
Product type: Primary antibody
Antigen: Smad3
Immunogen: Peptide
Species immunized: Mouse
Isotype: IgG1
Applications: Western Blot ( 1:300-1:1000 ); Immunoprecipitation ( 1-3 μg per 100-500 μg of total protein ( 1 ml of cell lysate ) ); Immunohistochemistry ( 1:30-1:500 ); Immunohistochemistry ( 1:80-1:500 )
Reactivity: Mouse, Rat and Human
Clonality (clone number): Monoclonal ( 80 )
Form: Liquid
Buffer: Tris-HCl buffer ( pH7.4 ), 1 % BSA, 40 % glycerol, 0.05 % NaN3.
Concentration: 1 mg/ml
Purity: Protein A affinity purified
Storage: Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles.
Alternative names: DKFZP586N0721 Antibody
DKFZp686J10186 Antibody
hMAD 3 Antibody
hMAD-3 Antibody
hSMAD3 Antibody
HSPC193 Antibody
HST17436 Antibody
JV15 2 Antibody
JV15-2 Antibody
JV152 Antibody
LDS1C Antibody
LDS3 Antibody
MAD (Mothers Against Decapentaplegic Drosophila) Homolog 3 Antibody
MAD Homolog 3 Antibody
Mad Homolog JV15 2 Antibody
Mad Protein Homolog Antibody
MAD, MothersAgainstDecapentaplegic Homolog 3 Antibody
Mad3 Antibody
MADH 3 Antibody
MADH3 Antibody
MGC60396 Antibody
Mothers Against Decapentaplegic Homolog 3 Antibody
Mothers Against DPP Homolog 3 Antibody
SMA and MAD Related Protein 3 Antibody
SMAD 3 Antibody
SMADAntibody
SMAD Family Member 3 Antibody
SMAD, Mothers Against DPP Homolog 3 Antibody
Smad3 Antibody
SMAD3_HUMAN Antibody
展开

靶标信息

Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.

产品来源

洱畔科技实验室

文件下载

MSDS-AB-06-4116.pdf (下载178)