购物车里没有产品

Anti-SIRT7 antibody

产品货号 产品 品牌 单位 存货 价格 促销价 数量  
AB-06-4072
Anti-SIRT7 antibody
洱畔/Erpan Tech 有货

产品特性        

Product Cat#: AB-06-4072
Product type: Primary antibody
Antigen: SIRT7
Immunogen: Recombinant protein
Species immunized: Mouse
Isotype: IgG
Applications: Western Blot ( 1:800-1:2000 ); Immunohistochemistry ( 1:80-1:200 )
Reactivity: Human
Clonality (clone number): Monoclonal (G10-E2)
Form: Liquid
Buffer: Tris-HCl buffer ( pH7.4 ), 1 % BSA, 40 % glycerol, 0.05 % NaN3.
Concentration: 1 mg/ml
Purity: Protein A affinity purified
Storage: Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles.
Alternative names: NAD Dependent Deacetylase Sirtuin 7 Antibody
NAD Dependent Protein Deacetylase Sirtuin 7 Antibody
NAD-dependent Protein Deacetylase Sirtuin-7 Antibody
Regulatory Protein SIR2 Homolog 7 Antibody
Silent Mating Type Information Regulation 2 Homolog Antibody
展开

靶标信息

NAD-dependent protein deacetylase that specifically mediates deacetylation of histone H3 at ‘Lys-18’ (H3K18Ac). In contrast to other histone deacetylases, displays selectivity for a single histone mark, H3K18Ac, directly linked to control of gene expression. H3K18Ac is mainly present around the transcription start site of genes and has been linked to activation of nuclear hormone receptors. SIRT7 thereby acts as a transcription repressor. Moreover, H3K18 hypoacetylation has been reported as a marker of malignancy in various cancers and seems to maintain the transformed phenotype of cancer cells. These data suggest that SIRT7 may play a key role in oncogenic transformation by suppresses expression of tumor suppressor genes by locus-specific deacetylation of H3K18Ac at promoter regions. Also required to restore the transcription of ribosomal RNA (rRNA) at the exit from mitosis: promotes the association of RNA polymerase I with the rDNA promoter region and coding region. Stimulates transcription activity of the RNA polymerase I complex. May also deacetylate p53/TP53 and promotes cell survival, however such data need additional confirmation.

产品来源

洱畔科技实验室

文件下载

download id=”153550″]