Anti-SIRT5 antibody
产品特性
| Product Cat#: | AB-06-4069 |
| Product type: | Primary antibody |
| Antigen: | SIRT5 |
| Immunogen: | Recombinant protein |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot ( 1:800-1:2000 ) |
| Reactivity: | Mouse and Human |
| Clonality (clone number): | Monoclonal ( JJ084-01 ) |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer ( pH7.4 ), 1 % BSA, 40 % glycerol, 0.05 % NaN3. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | NAD Dependent Deacetylase Sirtuin 5 Antibody |
| NAD Dependent Lysine Demalonylase and Desuccinylase Sirtuin 5 Mitochondrial Antibody | |
| NAD Dependent Protein Deacylase Sirtuin 5 Mitochondrial Antibody | |
| NAD-dependent Protein deacylase Sirtuin-5, Mitochondrial Antibody | |
| Regulatory Protein SIR2 Homolog 5 Antibody | |
| Silent Mating Type Information Rgulation 2 S.cerevisiae Homolog 5 Antibody | |
| Sir2 like 5 Antibody | |
| SIR2-like Protein 5 Antibody | |
| SIR2L5 Antibody | |
| SIR5_HUMAN Antibody | |
| Sirt5 Antibody | |
| Sirtuin 5 Antibody |
靶标信息
NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Activates SHMT2 by mediating its desuccinylation. Modulates ketogenesis through the desuccinylation and activation of HMGCS2 (By similarity). Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro such as UOX.
产品来源
洱畔科技实验室
