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Anti-PHD2 antibody

产品货号 产品 品牌 单位 存货 价格 促销价 数量  
AB-06-3453
Anti-PHD2 antibody
洱畔/Erpan Tech 有货

产品特性        

Product Cat#: AB-06-3453
Product type: Primary antibody
Antigen: PHD2
Immunogen: Peptide
Species immunized: Rabbit
Isotype: IgG
Applications: Western Blot(1:900); Flow Cytometry(1:10-1:80); Immunocytochemistry(1:40-1:200); Immunohistochemistry (1:40-1:200)
Reactivity: Human, Mouse, Rat
Clonality (clone number): Polyclonal
Form: Liquid
Buffer: Tris-HCl buffer (pH7.4), 1% BSA;40% glycerol, 0.05% NaN3.
Concentration: 1 mg/ml
Purity: Peptide affinity purified
Storage: Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles.
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Chromosome 1 Open Reading Frame 12 antibody
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靶标信息

Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A. Also hydroxylates HIF2A. Has a preference for the CODD site for both HIF1A and HIF1B. Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy-inducible genes. EGLN1 is the most important isozyme under normoxia and, through regulating the stability of HIF1, involved in various hypoxia-influenced processes such as angiogenesis in retinal and cardiac functionality. Target proteins are preferentially recognized via a LXXLAP motif.

产品来源

洱泮科技实验室