Anti-CDC45 antibody
产品特性
| Product Cat#: | AB-06-0988 |
| Product type: | Primary antibody |
| Antigen: | CDC45 |
| Immunogen: | Recombinant protein |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:900); Immunohistochemistry (1:40-1:200); Flow Cytometry (1:40-1:100); Immunocytochemistry (1:80-1:500) |
| Reactivity: | Human, Mouse, Rat |
| Clonality (clone number): | Monoclonal (JJ091-04) |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 1% BSA, 40% Glycerol, 0.05% NaN3. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | CDC 45 antibody |
| CDC 45L antibody | |
| CDC45 (cell division cycle 45, S.cerevisiae homolog) like antibody | |
| CDC45 antibody | |
| CDC45 cell division cycle 45 like antibody | |
| CDC45 like antibody | |
| CDC45 related protein antibody | |
| CDC45_HUMAN antibody | |
| CDC45L2 antibody | |
| Cell division control protein 45 homolog antibody | |
| Cell division cycle 45 like 2 antibody | |
| Cell division cycle 45 like antibody | |
| PORC PI 1 antibody | |
| PORC-PI-1 antibody |
靶标信息
Cell cycle events are regulated by the sequential activation and deactivation of cyclin dependent kinases (Cdks) and by the proteolysis of cyclins. The cell division cycle (Cdc) genes are required at various points in the cell cycle. Cdc25A, Cdc25B and Cdc25C protein tyrosine phosphatases function as mitotic activators by dephosphorylating Cdc2 p34 on regulatory tyrosine residues. Cdc6 and Cdc45 are the mammalian homologs of S. cerevisiae Cdc6 and Cdc45, which are involved in the initiation of DNA replication. Cdc37 appears to facilitate Cdk4/cyclin D1 complex formation and has been shown to form a stable complex with HSP 90. Cdc34, Cdc27 and Cdc16 function as ubiquitin-conjugating enzymes. Cdc34 is thought to be the structural and functional homolog of S. cerevisiae Cdc34, which is essential for the G1 to S phase transition. Cdc16 and Cdc27 are components of the APC (anaphase-promoting complex) which ubiquitinates cyclin B, resulting in cyclin B/Cdk complex degradation.
产品来源
洱畔科技实验室
