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Anti-ZBTB7B antibody

产品货号 产品 品牌 单位 存货 价格 促销价 数量  
AB-06-4690
Anti-ZBTB7B antibody
洱畔/Erpan Tech 有货

产品特性        

Product Cat#: AB-06-4690
Product type: Primary antibody
Antigen: ZBTB7B
Immunogen: Purified recombinant fragment of human ZBTB7B expressed in E. Coli
Species immunized: Mouse
Isotype: IgG1
Applications: Western Blot (1:500-1:1000); Immunohistochemistry (1:100-1:200); Immunocytochemistry (1:50-1:200)
Reactivity: Human
Clonality (clone number): Monoclonal (C12-C12)
Form: Liquid
Buffer: Tris-HCl buffer (pH7.4), 1% BSA, 40% glycerol, 0.05% NaN3.
Concentration: 1 mg/ml
Purity: Protein A affinity purified
Storage: Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles.
Alternative names: c Krox antibody cKrox antibody DKFZp686G01254 antibody hc Krox antibody hcKrox antibody Krueppel-related zinc finger protein cKrox antibody Kruppel related zinc finger protein c Krox antibody Kruppel related zinc finger protein cKrox antibody Kruppel related zinc finger protein hcKrox antibody T helper inducing POZ/Kruppel like factor antibody T-helper-inducing POZ/Krueppel-like factor antibody Th-POK antibody ThPOK antibody ZBT7B_HUMAN antibody ZBTB 15 antibody ZBTB 7B antibody ZBTB15 antibody ZBTB7B antibody ZFP 67 antibody Zfp-67 antibody ZFP67 antibody Zinc finger and BTB domain containing 15 antibody Zinc finger and BTB domain containing 7B antibody Zinc finger and BTB domain containing protein 15 antibody Zinc finger and BTB domain containing protein 7B antibody Zinc finger and BTB domain-containing protein 15 antibody Zinc finger and BTB domain-containing protein 7B antibody Zinc finger protein 67 homolog antibody Zinc finger protein 857B antibody Zinc finger protein Th POK antibody Zinc finger protein Th-POK antibody Zinc finger protein ThPOK antibody ZNF857B antibody
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靶标信息

Transcription regulator that acts as a key regulator of lineage commitment of immature T-cell precursors. Exerts distinct biological functions in the mammary epithelial cells and T cells in a tissue-specific manner. Necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. Development of immature T-cell precursors (thymocytes) to either the CD4 helper or CD8 killer T-cell lineages correlates precisely with their T-cell receptor specificity for major histocompatibility complex class II or class I molecules, respectively. Cross-antagonism between ZBTB7B and CBF complexes are determinative to CD4 versus CD8 cell fate decision. Suppresses RUNX3 expression and imposes CD4+ lineage fate by inducing the SOCS suppressors of cytokine signaling. induces, as a transcriptional activator, SOCS genes expression which represses RUNX3 expression and promotes the CD4+ lineage fate. During CD4 lineage commitment, associates with multiple sites at the CD8 locus, acting as a negative regulator of the CD8 promoter and enhancers by epigenetic silencing through the recruitment of class II histone deacetylases, such as HDAC4 and HDAC5, to these loci. Regulates the development of IL17-producing CD1d-restricted naural killer (NK) T cells. Also functions as an important metabolic regulator in the lactating mammary glands. Critical feed-forward regulator of insulin signaling in mammary gland lactation, directly regulates expression of insulin receptor substrate-1 (IRS-1) and insulin-induced Akt-mTOR-SREBP signaling (By similarity). Transcriptional repressor of the collagen COL1A1 and COL1A2 genes. May also function as a repressor of fibronectin and possibly other extracellular matrix genes (PubMed:9370309). Potent driver of brown fat development, thermogenesis and cold-induced beige fat formation. Recruits the brown fat lncRNA 1 (Blnc1):HNRNPU ribonucleoprotein complex to activate thermogenic gene expression in brown and beige adipocytes (By similarity).

产品来源

洱畔科技实验室

文件下载

MSDS-AB-06-4690.pdf (下载288)