Anti-TCF7L2 antibody (Copy) (Copy)
产品特性
| Product Cat#: | AB-06-4388 |
| Product type: | Primary antibody |
| Antigen: | TMP21 |
| Immunogen: | KLH conjugated synthetic peptide derived from human TMP21 101-200/219 |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:400-1:2000); Immunohistochemistry-Paraffin (1:500-1:800) |
| Reactivity: | Human, Mouse, Rat, Chicken, Dog, Cow, Rabbit |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | 10 mM Tris-HCl buffer (pH 7.4), 1% BSA, 50% glycerol, 0.03% Proclin300. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | P23 |
| P24 family protein delta 1 | |
| P24delta | |
| P24delta1 | |
| S31I125 | |
| S31III125 | |
| TMED 10 | |
| TMED10 | |
| Tmp 21 I | |
| Tmp 21 | |
| Tmp 21 I | |
| Transmembrane emp24 domain containing protein 10 | |
| Transmembrane emp24-like trafficking protein 10 (yeast) | |
| Transmembrane protein Tmp21 | |
| Transmembrane trafficking protein 21kD | |
| 1110014C03Rik | |
| 21 kDa transmembrane trafficking protein | |
| MGC102351 |
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靶标信息
Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. Acts as repressor in the absence of CTNNB1, and as activator in its presence. Activates transcription from promoters with several copies of the Tcf motif 5′-CCTTTGATC-3′ in the presence of CTNNB1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7L2/TCF4 and CTNNB1. Expression of dominant-negative mutants results in cell-cycle arrest in G1. Necessary for the maintenance of the epithelial stem-cell compartment of the small intestine.
产品来源
洱畔科技实验室
