Anti-RNF43 antibody
产品特性
| Product Cat#: | AB-06-3901 |
| Product type: | Primary antibody |
| Antigen: | RNF43 |
| Immunogen: | KLH conjugated synthetic peptide derived from human RNF43 41-140/783 |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:500-1:2000); Immunohistochemistry-Paraffin (1:400-1:800) |
| Reactivity: | Human, Mouse, Rat, Dog, Cow, Horse, Rabbit |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | 10 mM Tris-HCl buffer (pH7.4), 1% BSA, 50% Glycerol, 0.03% Proclin300. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| Alternative names: | RNF124 |
| Ring finger protein 43 | |
| URCC | |
| RNF43_HUMAN | |
| E3 ubiquitin-protein ligase RNF43 |
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靶标信息
E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination, endocytosis and subsequent degradation of Wnt receptor complex components Frizzled. Acts on both canonical and non-canonical Wnt signaling pathway (PubMed:18313049, PubMed:22575959, PubMed:22895187). Along with RSPO2 and ZNRF3, constitutes a master switch that governs limb specification (By similarity).
产品来源
洱畔科技实验室
