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Anti-Tim3 antibody

产品货号 产品 品牌 单位 存货 价格 促销价 数量  
AB-06-4357
Anti-Tim3 antibody
洱畔/Erpan Tech 有货

产品特性        

Product Cat#: AB-06-4357
Product type: Primary antibody
Antigen: Tim3
Immunogen: Recombinant protein
Species immunized: Mouse
Isotype: IgG1
Applications: Western Blot (1:400-1:2000); Immunocytochemistry (1:40-1:200); Immunohistochemistry (1:80-1:200); Flow Cytometry (1:40-1:100)
Reactivity: Human
Clonality (clone number): Monoclonal (1E3)
Form: Liquid
Buffer: Tris-HCl buffer (pH7.4), 0.5% BSA, 50% glycerol, 0.05% NaN3.
Concentration: 2 mg/ml
Purity: Protein A affinity purified
Storage: Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles.
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靶标信息

Cell surface receptor implicated in modulating innate and adaptive immune responses. Generally accepted to have an inhibiting function. Reports on stimulating functions suggest that the activity may be influenced by the cellular context and/or the respective ligand. Regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. In CD8+ cells attenuates TCR-induced signaling, specifically by blocking NF-kappaB and NFAT promoter activities resulting in the loss of IL-2 secretion. The function may implicate its association with LCK proposed to impair phosphorylation of TCR subunits, and/or LGALS9-dependent recruitment of PTPRC to the immunological synapse. In contrast, shown to activate TCR-induced signaling in T-cells probably implicating ZAP70, LCP2, LCK and FYN (By similarity). Expressed on Treg cells can inhibit Th17 cell responses.

产品来源

洱畔科技实验室

文件下载

MSDS-AB-06-4357.pdf (下载194 )