Anti-TCF7L2 antibody (Copy) (Copy)
产品特性
| Product Cat#: | AB-06-4337 |
| Product type: | Primary antibody |
| Antigen: | Thioredoxin |
| Immunogen: | Peptide |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:400); Immunohistochemistry (1:40-1:100); Flow Cytometry (1:40-1:100); Immunocytochemistry (1:40-1:200) |
| Reactivity: | Human, Mouse |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 1% BSA, 40% glycerol, 0.05% NaN3. |
| Concentration: | 1 mg/ml |
| Purity: | Peptide affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | ADF antibody |
| ATL-derived factor antibody | |
| SASP antibody | |
| Surface associated sulphydryl protein antibody | |
| TRN antibody | |
| TXN 1 antibody | |
| TXN antibody |
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靶标信息
Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. Acts as repressor in the absence of CTNNB1, and as activator in its presence. Activates transcription from promoters with several copies of the Tcf motif 5′-CCTTTGATC-3′ in the presence of CTNNB1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7L2/TCF4 and CTNNB1. Expression of dominant-negative mutants results in cell-cycle arrest in G1. Necessary for the maintenance of the epithelial stem-cell compartment of the small intestine.
产品来源
洱畔科技实验室
