Anti-HIPK1 antibody
Specifications
| Product Cat#: | AB-06-2167 |
| Product type: | Primary antibody |
| Antigen: | HIPK1 |
| Immunogen: | KLH conjugated synthetic peptide derived from human HIPK1 1-100/1210 |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:600-1:2000); Immunohistochemistry-Paraffin (1:500-1:800) |
| Reactivity: | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, Macaque Monkey |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4),with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | Hipk 1 |
| Hipk1 | |
| HIPK1_HUMAN | |
| Homeodomain interacting protein kinase 1 | |
| Homeodomain interacting protein kinase 1 like protein | |
| Homeodomain-interacting protein kinase 1 | |
| Myak | |
| Nbak 2 | |
| Nbak2 | |
| Nuclear body associated kinase 2 |
靶标信息
Serine/threonine-protein kinase involved in transcription regulation and TNF-mediated cellular apoptosis. Plays a role as a corepressor for homeodomain transcription factors. Phosphorylates DAXX and MYB. Phosphorylates DAXX in response to stress, and mediates its translocation from the nucleus to the cytoplasm. Inactivates MYB transcription factor activity by phosphorylation. Prevents MAP3K5-JNK activation in the absence of TNF. TNF triggers its translocation to the cytoplasm in response to stress stimuli, thus activating nuclear MAP3K5-JNK by derepression and promoting apoptosis. May be involved in anti-oxidative stress responses. Involved in the regulation of eye size, lens formation and retinal lamination during late embryogenesis. Promotes angiogenesis and to be involved in erythroid differentiation. May be involved in malignant squamous cell tumor formation.
产品来源
洱畔科技实验室
