Anti-EphA7 antibody
产品特性
| Product type: | Primary antibody |
| Antigen: | EphA7 |
| Immunogen: | KLH conjugated synthetic peptide derived from human EphA7 181-280/998 |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:200-1:1500); Immunohistochemistry-Paraffin (1:250-800) |
| Reactivity: | Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Rabbit |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| Concentration: | 1mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | Cek 11 |
| Developmental kinase 1 | |
| EBK | |
| EHK-3 | |
| EHK3 | |
| EK11 | |
| Embryonic brain kinase | |
| Eph homology kinase 3 | |
| Eph receptor A7 | |
| EPH-like kinase 11 | |
| EphA7 | |
| EPHA7_HUMAN | |
| Ephrin receptor Eph A7 | |
| Ephrin type A receptor 7 | |
| Ephrin type-A receptor 7 | |
| hEK11 | |
| MDK 1 | |
| Receptor protein tyrosine kinase HEK 11 |
靶标信息
Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 is a cognate/functional ligand for EPHA7 and their interaction regulates brain development modulating cell-cell adhesion and repulsion. Has a repellent activity on axons and is for instance involved in the guidance of corticothalamic axons and in the proper topographic mapping of retinal axons to the colliculus. May also regulate brain development through a caspase(CASP3)-dependent proapoptotic activity. Forward signaling may result in activation of components of the ERK signaling pathway including MAP2K1, MAP2K2, MAPK1 AND MAPK3 which are phosphorylated upon activation of EPHA7.
产品来源
洱泮科技实验室
