Anti-TCF7L2 antibody
产品特性
| Product Cat#: | AB-06-4291 |
| Product type: | Primary antibody |
| Antigen: | TCF7L2 |
| Immunogen: | Recombinant protein |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:400-1:1000); Immunohistochemistry (1:100-1:200); Flow Cytometry (1:50-1:200); Immunocytochemistry (1:100-1:200); Immunoprecipitation; Immunofluorescence |
| Reactivity: | Human, Mouse, Rat |
| Clonality (clone number): | Monoclonal (SC06-90) |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH 7.4), 1% BSA, 40% glycerol, 0.05% NaN3. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | HMG box transcription factor 4 antibody |
| HTCF 4 antibody | |
| HTCF-4 antibody | |
| T cell factor 4 antibody | |
| T cell specific HMG box antibody | |
| T cell specific transcription factor 4 antibody | |
| T-cell factor 4 antibody | |
| T-cell-specific transcription factor 4 antibody | |
| TCF 4 antibody | |
| TCF-4 antibody | |
| TCF4 antibody | |
| TCF7L2 antibody | |
| TCF7L2 protein antibody | |
| TF7L2_HUMAN antibody | |
| Transcription factor 7 like 2 antibody | |
| Transcription factor 7 like 2 T cell specific HMG box antibody | |
| Transcription factor 7-like 2 antibody |
展开
靶标信息
Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. Acts as repressor in the absence of CTNNB1, and as activator in its presence. Activates transcription from promoters with several copies of the Tcf motif 5′-CCTTTGATC-3′ in the presence of CTNNB1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7L2/TCF4 and CTNNB1. Expression of dominant-negative mutants results in cell-cycle arrest in G1. Necessary for the maintenance of the epithelial stem-cell compartment of the small intestine.
产品来源
洱畔科技实验室