Anti-TAB1 antibody
产品特性
| Product Cat#: | AB-06-4266 |
| Product type: | Primary antibody |
| Antigen: | TAB1 |
| Immunogen: | Peptide |
| Species immunized: | Mouse |
| Isotype: | IgG1 |
| Applications: | Western Blot (1:200-1:1000); Immunoprecipitation [1-2 μg per 100-500 μg of total protein(1 ml of cell lysate) ]; Immunofluorescence (1:100-1:200) |
| Reactivity: | Human |
| Clonality (clone number): | Monoclonal (1G2) |
| Form: | Liquid |
| Buffer: | 1*TBS (pH 7.4), 1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide. |
| Concentration: | 1 mg/ml |
| Purity: | Immunogen affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | 2310012M03Rik antibody |
| 3'-Tab1 antibody | |
| MAP3K7IP 1 antibody | |
| MAP3K7IP1 antibody | |
| MGC57664 antibody | |
| Mitogen activated protein kinase kinase kinase 7 interacting protein 1 antibody | |
| Mitogen-activated protein kinase kinase kinase 7-interacting protein 1 antibody | |
| TAB 1 antibody | |
| TAB1 antibody | |
| TAB1_HUMAN antibody | |
| TAK1 binding protein 1 antibody | |
| TAK1-binding protein 1 antibody | |
| TGF beta activated kinase 1 binding protein 1 antibody | |
| TGF-beta activated kinase 1/MAP3K7 binding protein 1 antibody | |
| TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 antibody |
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靶标信息
The TAK1 binding proteins, TAB1, TAB2 and TAB3, interact with the MAPKKK TAK1 in response to various stimuli. TAB1 activates TAK1 in TGFβ mediated signaling. TAB1 also plays a central role in a p38α activation pathway that is independent of MAPKK. In response to pro-inflammatory signals, TAB2 complexes with TRAF6 and TAK1, leading to translocation of the complex from the membrane to the cytosol and the subsequent activation of TAK1. When overexpressed, TAB3 activates both NFκB and AP-1 transcription factors. In response to TNFα or IL-1, TAK1 complexes with TAB1 and TAB2 or with TAB1 and TAB3 to yield two distinct complexes.
产品来源
洱畔科技实验室