Anti-DNMT3A antibody
产品特性
| Product Cat#: | AB-06-1423 |
| Product type: | Primary antibody |
| Antigen: | DNMT3A |
| Immunogen: | Purified recombinant fragment of human DNMT3A expressed in E. Coli. |
| Species immunized: | Mouse |
| Isotype: | IgG2a |
| Applications: | Western Blot (1:400-1:2000); Immunohistochemistry (1:100-1:200); Flow Cytometry (1:100-1:200) |
| Reactivity: | Human |
| Clonality (clone number): | Monoclonal (F5-G11) |
| Form: | Liquid |
| Buffer: | TBS (pH7.4), 1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | DNA (cytosine 5) methyltransferase 3 alpha antibody |
| DNA (cytosine 5) methyltransferase 3A antibody | |
| DNA (cytosine-5)-methyltransferase 3A antibody | |
| DNA cytosine methyltransferase 3A2 antibody | |
| DNA methyltransferase 3 alpha antibody | |
| DNA methyltransferase 3a antibody | |
| DNA methyltransferase HsaIIIA antibody | |
| DNA MTase HsaIIIA antibody |
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靶标信息
Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Recruited to trimethylated ‘Lys-36’ of histone H3 (H3K36me3) sites. Can actively repress transcription through the recruitment of HDAC activity.
产品来源
洱畔科技实验室
