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Anti-IKK Alpha + IKK Beta antibody

产品货号 产品 品牌 单位 存货 价格 促销价 数量  
AB-06-2381
Anti-IKK Alpha + IKK Beta antibody
洱畔/Erpan Tech 有货

产品特性        

Product Cat#: AB-06-2381
Product type: Primary antibody
Antigen: IKK alpha + IKK beta
Immunogen: Recombinant protein
Species immunized: Rabbit
Isotype: IgG
Applications: Western Blot (1:800-1:2000); Immunocytochemistry (1:80-1:200); Immunofluorescence; Immunoprecipitation
Reactivity: Mouse, Rat and Human
Clonality (clone number): Monoclonal(SN63-02)
Form: Liquid
Buffer: 1*TBS (pH7.4), 1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration: 1 mg/ml
Purity: Protein A affinity purified
Storage: Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles.
Alternative names: CHUK antibody
Conserved helix loop helix ubiquitous kinase antibody
I kappa B kinase 1 antibody
I kappa B kinase 2 antibody
I Kappa B kinase alpha antibody
I Kappa B kinase beta antibody
IkB kinase alpha subunit antibody
IkBKA antibody
IkBKB antibody
IKK a kinase antibody
IKK alpha antibody
IKK beta antibody
IKK1 antibody
IKK2 antibody
IKKA antibody
IKKB antibody
IMD15 antibody
Inhibitor of kappa light polypeptide gene enhancer in B cells kinase beta antibody
Inhibitor of nuclear factor kappa-B kinase subunit alpha antibody
Inhibitor of nuclear factor kappa-B kinase subunit beta antibody
NFKBIKA antibody
NFKBIKB antibody
Nuclear factor NF kappa B inhibitor kinase beta antibody
Nuclear factor NFkappaB inhibitor kinase alpha antibody
TCF 16 antibody
TCF16 antibody
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靶标信息

Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses (PubMed:30337470). Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation. Phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE. IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs. Phosphorylates FOXO3, mediating the TNF-dependent inactivation of this pro-apoptotic transcription factor. Also phosphorylates other substrates including NCOA3, BCL10 and IRS1. Within the nucleus, acts as an adapter protein for NFKBIA degradation in UV-induced NF-kappa-B activation.

产品来源

洱畔科技实验室

文件下载

MSDS-AB-06-2381.pdf (下载95)