Anti-KEAP1 antibody
产品特性
| Product Cat#: | AB-06-2579 |
| Product type: | Primary antibody |
| Antigen: | KEAP1 |
| Immunogen: | Recombinant protein |
| Species immunized: | Mouse |
| Isotype: | IgG1 |
| Applications: | Western Blot (1:500); Immunocytochemistry (1:50); Flow Cytometry (1:50-1:200) |
| Reactivity: | Human, Mouse |
| Clonality (clone number): | Monoclonal (B6-F10) |
| Form: | Liquid |
| Buffer: | TBS (pH7.4), 1% BSA, Preservative: 0.05% Sodium Azide. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Alternative names: | Cytosolic Inhibitor of Nrf2 antibody |
| INrf 2 antibody | |
| INrf2 antibody | |
| Keap 1 antibody | |
| KEAP1 antibody | |
| KEAP1_HUMAN antibody | |
| Kelch Like ECH Associated Protein 1 antibody | |
| Kelch Like Family Member 19 antibody | |
| Kelch Like Protein 19 antibody | |
| Kelch-Like ECH-Associated Protein 1 antibody | |
| Kelch-Like Protein 19 antibody | |
| KIAA0132 antibody | |
| KLHL 19 antibody | |
| KLHL19 antibody | |
| MGC10630 antibody | |
| MGC1114 antibody | |
| MGC20887 antibody | |
| MGC4407 antibody | |
| MGC9454 antibody |
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靶标信息
Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome.
产品来源
洱畔科技实验室
