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Anti-JAB1 antibody

产品货号 产品 品牌 单位 存货 价格 促销价 数量  
AB-06-2521
Anti-JAB1 antibody
洱畔/Erpan Tech 有货

产品特性        

Product type: Primary antibody
Antigen: JAB1
Immunogen: Recombinant protein
Species immunized: Rabbit
Isotype: IgG
Applications: Western Blot (1:500); Immunohistochemistry (1:50-1:200); Immunocytochemistry (1:100-1:200); Immunoprecipitation; Immunofluorescence
Reactivity: Human, Mouse, Rat
Clonality (clone number): Monoclonal (JB34-96)
Form: Liquid
Buffer: 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
Concentration: 1 mg/ml
Purity: Protein A affinity purified
Storage: Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
Alternative names: 38 kDa Mov34 homolog antibody
COP9 (constitutive photomorphogenic) homolog subunit 5 antibody
COP9 constitutive photomorphogenic homolog subunit 5 antibody
COP9 signalosome complex subunit 5 antibody
COP9 signalosome subunit 5 antibody
Cop9 subunit 5 antibody
COPS 5 antibody
cops5 antibody
CSN 5 antibody
CSN5 antibody
CSN5_HUMAN antibody
JAB 1 antibody
Jun activation domain binding protein 1 antibody
Jun activation domain binding protein antibody
Jun activation domain-binding protein 1 antibody
MGC3149 antibody
MOV 34 antibody
MOV34 antibody
MOV34 family, 38-KD member antibody
SGN 5 antibody
SGN5 antibody
Signalosome subunit 5 antibody

 

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靶标信息

Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. In the complex, it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of the CSN complex. Interacts directly with a large number of proteins that are regulated by the CSN complex, confirming a key role in the complex. Promotes the proteasomal degradation of BRSK2.

产品来源

洱畔科技实验室

文件下载

MSDS-AB-06-2521.pdf (下载114)