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Anti-SN38 Recombinant Rabbit Monoclonal antibody

产品货号 产品 品牌 单位 存货 价格 促销价 数量  
AB-06-5103
Anti-SN38 Recombinant Rabbit Monoclonal antibody
洱畔/Erpan Tech 有货

产品特性        

Product Cat#: AB-06-5103
Product type: Primary antibody
Antigen: SN38
Immunogen: SN38-OVA
Species immunized: Rabbit
Isotype: IgG
Applications: Western Blot (1:500-1:2000); ELISA (1:5000-1:10000)
Reactivity: Species independent
Clonality (clone number): Monoclonal, PSH0-05
Form: Liquid
Buffer: 1*PBS buffer (pH7.4), 40% glycerol, 0.1% BSA, 0.05% NaN3.
Concentration: 1 μg/μL
Purity: Protein A affinity purified
Storage: Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles.
Alternative names: SN-38 antibody
SN38 antibody
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靶标信息

SN-38 is an antineoplastic drug. It is the active metabolite of irinotecan (an analog of camptothecin – a topoisomerase I inhibitor) but has 1000 times more activity than irinotecan itself. In vitro cytotoxicity assays show that the potency of SN-38 relative to irinotecan varies from 2- to 2000-fold. SN38 is formed via hydrolysis of irinotecan by carboxylesterases and metabolized via glucuronidation by UGT1A1. The variant of UGT1A1 in ~10% of Caucasians which leads to poor metabolism of SN-38 predicts irinotecan toxicity, as it is then less easily excreted from the body in its SN-38 glucuronide form. SN-38 and its glucuronide are lost into the bile and intestines. It can cause the symptoms of diarrhoea and myelosuppression experienced by ~25% of the patients administered irinotecan.

产品来源

洱畔科技实验室