E-cadherin Monoclonal Antibody (HECD-1)
产品特性
| Product Cat#: | 13-1700 |
| Product type: | Primary antibody |
| Antigen: | E-cadherin |
| Immunogen: | Human breast tumor cell line MCF-7. |
| Species immunized: | Mouse |
| Isotype: | IgG1 |
| Applications: | WB; IHC (P); IHC (F); ICC/IF; Flow; ELISA; IA |
| Reactivity: | Human, Guinea pig |
| Clonality (clone number): | Monoclonal, HECD-1 |
| Form: | Liquid |
| Buffer: | 10mM PBS, pH 7.4, with 1% BSA |
| Concentration: | 2 mg/mL |
| Purity: | Ion-exchange chromatography |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | cadherin 1, E-cadherin (epithelial); cadherin 1, type 1; cadherin 1, type 1, E-cadherin (epithelial); cadherin e; Cadherin-1; cadherin-E; calcium-dependent adhesion protein, epithelial; CAM 120/80; CD324; cell-CAM 120/80; E-Cadherin; E-cadherin 1; Ecadherin; Epithelial cadherin; Uvomorulin; Arc-1; CD324; CDH1; CDHE; ECAD; LCAM; UVO |
靶标信息
Cadherins are calcium-dependent cell adhesion proteins (PubMed:11976333).
They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells (PubMed:11976333).
Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7.
相关文献
1、Wang J, Wang W, Huang X, Cao J, Hou S, Ni X, Peng C, Liu T. m6A-dependent upregulation of TRAF6 by METTL3 is associated with metastatic osteosarcoma. J Bone Oncol. 2022 Jan 19;32:100411. doi: 10.1016/j.jbo.2022.100411. PMID: 35145841; PMCID: PMC8802048.
2、Yang M, Li Z, Tao J, Hu H, Li Z, Zhang Z, Cheng F, Sun Y, Zhang Y, Yang J, Wei H, Wu Z. Resveratrol induces PD-L1 expression through snail-driven activation of Wnt pathway in lung cancer cells. J Cancer Res Clin Oncol. 2021 Apr;147(4):1101-1113. doi: 10.1007/s00432-021-03510-z. Epub 2021 Jan 20. PMID: 33471184; PMCID: PMC7954741.
3、Xiang T, Yuan C, Guo X, Wang H, Cai Q, Xiang Y, Luo W, Liu G. The novel ZEB1-upregulated protein PRTG induced by Helicobacter pylori infection promotes gastric carcinogenesis through the cGMP/PKG signaling pathway. Cell Death Dis. 2021 Feb 4;12(2):150. doi: 10.1038/s41419-021-03440-1. PMID: 33542225; PMCID: PMC7862680.