Recombinant Mouse IL-1 Beta Protein
产品特性
| Synonyms: | Interleukin-1 beta; Catabolin; IL1F2; IL1B |
| Product Description: | Recombinant Mouse Interleukin-1 Beta is produced by our E.coli expression system and the target gene encoding Val118-Ser269 is expressed. |
| UniProt ID: | P10749 |
| Species: | Mouse |
| Expression System: | E.coli |
| Tag: | Tag free |
| Predicted MW: | 17.4 KDa |
| SDS-PAGE: | 16 KDa, reducing conditions |
| Formulation: | Lyophilized from a 0.2 μm filtered solution of 50mM Tris-HCl, 50mM NaCl, pH 8.0. |
| Endotoxin Level: | Less than 0.001 ng/µg (0.01 EU/µg) as determined by LAL test. |
| Purity: | >95% |
| Reconstitution: | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. |
| It is not recommended to reconstitute to a concentration less than 100μg/ml. | |
| Dissolve the lyophilized protein in distilled water. | |
| Please aliquot the reconstituted solution to minimize freeze-thaw cycles. | |
| Stability and Storage: | Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. |
| Reconstituted protein solution can be stored at 4-7°C for 2-7 days. | |
| Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
产品背景
Potent pro-inflammatory cytokine (PubMed:3920526, PubMed:10653850, PubMed:12794819).
Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production (PubMed:3920526).
Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells (PubMed:10653850).
Plays a role in angiogenesis by inducing VEGF production synergistically with TNF and IL6 (PubMed:12794819).
Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore (PubMed:33377178, PubMed:33883744).
产品来源
洱畔科技实验室
