Anti-ZO-1 Polyclonal antibody (KD/KO VALIDATED)
产品特性
| Product Cat#: | 21773-1-AP |
| Product type: | Primary antibody |
| Antigen: | ZO-1 |
| Immunogen: | The immunogen of 21773-1-AP is ZO-1 Fusion Protein expressed in E. coli. |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:5000-1:50000), Immunoprecipitation (IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB), Immunofluorescence (1:1000-1:4000), Flow Cytometry, ELISA |
| Reactivity: | Human, Canine, Mouse, Rat, Hamster |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | PBS buffer (pH7.3), 50% Glycerol, 0.02% NaN3. |
| Concentration: | 800 μg/ml |
| Purity: | Immunogen affinity purified. |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Conjugate: | Unconjugated |
| Alternative names: | Tight junction protein 1, Tight junction protein ZO 1, TJP1, ZO 1, ZO1, ZO-1, Zona occludens protein 1, Zonula occludens |
靶标信息
TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688).
The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity).
Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187).
Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113).
With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity).
产品来源
proteintech-https://www.ptgcn.com/products/ZO1-Antibody-21773-1-AP.htm
