产品特性

Product Cat#:	AB-08-0112
Product type:	Primary antibody
Antigen:	FCHO2
Immunogen:	Recombinant protein containing a sequence corresponding to amino acids 1-300 of human FCHO2.
Species immunized:	Rabbit
Isotype:	IgG
Applications:	Western Blot (1:400-1:2000)
Reactivity:	Human, Mouse
Clonality (clone number):	Polyclonal
Form:	Liquid
Buffer:	1*PBS buffer (pH7.3), 50% Glycerol, 0.02% NaN3.
Purity:	Immunogen affinity purified
Storage:	Aliquot and freeze at -20°C. Avoid multiple freeze/thaw cycles.
Conjugate:	Unconjugated
Alternative names:	FCH And Mu Domain Containing Endocytic Adaptor 2; F-BAR Domain Only Protein 2; FCH Domain Only 2; FCH Domain Only Protein 2

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靶标信息

Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a lipid-binding activity with a preference for membranes enriched in phosphatidylserine and phosphoinositides (Pi(4,5) biphosphate) like the plasma membrane. Its membrane-bending activity might be important for the subsequent action of clathrin and adaptors in the formation of clathrin-coated vesicles. Involved in adaptor protein complex AP-2-dependent endocytosis of the transferrin receptor, it also functions in the AP-2-independent endocytosis of the LDL receptor.

产品来源

洱畔科技实验室