Anti-CREBBP antibody
产品特性
| Product Cat#: | AB-06-4855 |
| Product type: | Primary antibody |
| Antigen: | CREBBP |
| Immunogen: | Synthetic peptide within C-terminal human CREBBP. |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:400-1:1000); Immunohistochemistry-Paraffin (1:400-1000) |
| Reactivity: | Human, Mouse and Rat |
| Clonality: | Polyclonal |
| Form: | Liquid |
| Buffer: | 1*TBS buffer (pH7.4), 0.2% BSA, 50% Glycerol, 0.05% NaN3. |
| Concentration: | 1 mg/ml |
| Purity: | Immoungen affinity purified. |
| Storage: | Aliquot and freeze at -20°C. Avoid multiple freeze/thaw cycles. |
| Conjugate: | Unconjugated |
| Alternative names: | CBP antibody |
| CBP_HUMAN antibody | |
| CREB binding protein antibody | |
| CREB-binding protein antibody | |
| Crebbp antibody | |
| Cyclic AMP responsive enhancer binding protein antibody | |
| KAT3A antibody | |
| RSTS antibody | |
| RTS antibody | |
| Rubinstein Taybi syndrome antibody |
靶标信息
Acetylates histones, giving a specific tag for transcriptional activation (PubMed:24616510).
Also acetylates non-histone proteins, like DDX21, FBL, IRF2, MAFG, NCOA3, POLR1E/PAF53 and FOXO1 (PubMed:10490106, PubMed:11154691, PubMed:12738767, PubMed:12929931, PubMed:9707565, PubMed:24207024, PubMed:28790157, PubMed:30540930).
Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers (PubMed:14645221).
Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902).
Acetylates POLR1E/PAF53, leading to decreased association of RNA polymerase I with the rDNA promoter region and coding region (PubMed:24207024).
Acetylates DDX21, thereby inhibiting DDX21 helicase activity (PubMed:28790157).
Acetylates FBL, preventing methylation of ‘Gln-105’ of histone H2A (H2AQ104me) (PubMed:30540930).
Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway (PubMed:25514493).
产品来源
洱畔科技实验室
