Anti-GDF15 antibody
产品特性
| Product Cat#: | AB-06-1873 |
| Product type: | Primary antibody |
| Antigen: | GDF15 |
| Immunogen: | KLH conjugated synthetic peptide derived from human GDF-15 221-308/308 |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:500-1:2000); Immunohistochemistry-Paraffin (1:400-1:800) |
| Reactivity: | Human, Mouse, Rat |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| Alternative names: | GDF 15 |
| GDF-15 Growth differentiation factor 15 | |
| Growth/differentiation factor 15 | |
| Macrophage inhibitory cytokine 1 | |
| MIC 1 | |
| MIC-1 | |
| MIC1 | |
| NAG 1 | |
| NAG1 | |
| NRG 1 | |
| NRG1 | |
| NSAID (nonsteroidal anti inflammatory drug) activated protein 1 | |
| NSAID | |
| NSAID regulated protein 1 | |
| PLAB | |
| Placental bone morphogenetic protein | |
| Placental bone morphogenic protein | |
| Placental TGF beta | |
| placental transformation growth factor beta | |
| Prostate differentiation factor | |
| PTGF beta | |
| PTGFB |
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靶标信息
Regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses (PubMed:28953886, PubMed:28846097, PubMed:28846098, PubMed:28846099, PubMed:23468844, PubMed:29046435). Binds to its receptor, GFRAL, and activates GFRAL-expressing neurons localized in the area postrema and nucleus tractus solitarius of the brainstem (PubMed:28953886, PubMed:28846097, PubMed:28846098, PubMed:28846099). It then triggers the activation of neurons localized within the parabrachial nucleus and central amygdala, which contitutes part of the ’emergency circuit’ that shapes feeding responses to stressful conditions (PubMed:28953886). On hepatocytes, inhibits growth hormone signaling (By similarity).
产品来源
洱畔科技实验室
