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Anti-RFA2 (Phospho-Ser33) antibody

SKU Product Brand Unit Availability Price 促销价 Quantity  
AB-07-3602
Anti-RFA2 (Phospho-Ser33) antibody
洱畔/Erpan Tech In stock

Specifications        

Product Cat#: AB-07-3602
Product type: Primary antibody
Antigen: RFA2 (Phospho-Ser33)
Immunogen: A synthetic peptide derived from human RFA2 around the phosphorylation site of serine 33 (A-P-SP-Q-A). The exact amino-acid sequence is proprietary.
Species immunized: Rabbit
Isotype: IgG
Applications: Western Blot (1:500-1:2500); ELISA (1:10000)
Reactivity: Human, Mouse, Rat
Clonality (clone number): Polyclonal
Form: Liquid
Buffer: PBS (without Mg2+ and Ca2+ ), pH 7.4, 150 mM NaCl, 0.02% sodium azide and 50% glycerol
Concentration: 1 mg/ml
Purity: Antigen affinity chromatography
Storage: Aliquot and freeze at -20°C. Avoid multiple freeze/thaw cycles.
Alternative names: REPA2; Replication factor-A protein 2; Replication protein A 32 kDa subunit; Replication protein A2; RF-A; RP-A; RPA2; RPA32
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靶标信息

As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response. It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage. Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair. Plays also a role in base excision repair (BER) probably through interaction with UNG. Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. May also play a role in telomere maintenance.

产品来源

洱畔科技实验室

文件下载

MSDS-AB-07-3602.pdf (下载51 )