Anti-DENND1B antibody
产品特性
| Product Cat#: | AB-06-1358 |
| Product type: | Primary antibody |
| Antigen: | DENND1B |
| Immunogen: | KLH conjugated synthetic peptide derived from human DENND1B 241-350/426 |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:400-1:2000) |
| Reactivity: | Human, Mouse, Rat, Dog, Cow, Horse, Rabbit |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | 0.01 M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | C1ORF18 |
| C1orf218 | |
| Chromosome 1 open reading frame 218 | |
| Connecdenn 2 | |
| DEN1B_HUMAN | |
| DENN domain containing protein 1B | |
| DENN domain-containing protein 1B | |
| DENN MADD domain containing 1B | |
| DENND1B | |
| DKFZp547O0715 | |
| FAM31B | |
| Family with sequence similarity 31 member B | |
| FLJ20054 | |
| FLJ21179 | |
| FLJ33888 | |
| MGC103810 | |
| MGC27044 |
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靶标信息
Guanine nucleotide exchange factor (GEF) for RAB35 that acts as a regulator of T-cell receptor (TCR) internalization in TH2 cells. Acts by promoting the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form. Plays a role in clathrin-mediated endocytosis . Controls cytokine production in TH2 lymphocytes by controlling the rate of TCR internalization and routing to endosomes: acts by mediating clathrin-mediated endocytosis of TCR via its interaction with the adapter protein complex 2 (AP-2) and GEF activity. Dysregulation leads to impaired TCR down-modulation and recycling, affecting cytokine production in TH2 cells.
产品来源
洱畔科技实验室
