Anti-DDX5 antibody
产品特性
| Product Cat#: | AB-06-1346 |
| Product type: | Primary antibody |
| Antigen: | DDX5 |
| Immunogen: | Purified recombinant fragment of human DDX5 expressed in E. Coli. |
| Species immunized: | Mouse |
| Isotype: | IgG2a |
| Applications: | Western Blot (1:400-1:2000); Immunohistochemistry (1:100-1:200); Flow Cytometry (1:50-1:200) |
| Reactivity: | Human, Mouse, Monkey |
| Clonality (clone number): | Monoclonal (C12-F1) |
| Form: | Liquid |
| Buffer: | 1*TBS (pH 7.4), 1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | ATP dependent RNA helicase DDX5 antibody |
| DDX 5 antibody | |
| Ddx5 antibody | |
| DDX5_HUMAN antibody | |
| DEAD (Asp Glu Ala Asp) box helicase 5 antibody | |
| DEAD (Asp Glu Ala Asp) box polypeptide 5 antibody | |
| DEAD box 5 antibody | |
| DEAD box protein 5 antibody | |
| DEAD/H (Asp Glu Ala Asp/His) box polypeptide 5 (RNA helicase, 68kD) antibody | |
| G17P1 antibody | |
| HELR antibody | |
| HLR1 antibody | |
| HUMP68 antibody | |
| P68 antibody | |
| P68 RNA helicase antibody | |
| Probable ATP dependent RNA helicase DDX5 antibody | |
| Probable ATP-dependent RNA helicase DDX5 antibody |
靶标信息
Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre-mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved in transcriptional regulation; the function is independent of the RNA helicase activity. Transcriptional coactivator for androgen receptor AR but probably not ESR1. Synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and involved in skeletal muscle differentiation. Transcriptional coactivator for p53/TP53 and involved in p53/TP53 transcriptional response to DNA damage and p53/TP53-dependent apoptosis. Transcriptional coactivator for RUNX2 and involved in regulation of osteoblast differentiation. Acts as transcriptional repressor in a promoter-specific manner; the function probably involves association with histone deacetylases, such as HDAC1. As component of a large PER complex is involved in the inhibition of 3′ transcriptional termination of circadian target genes such as PER1 and NR1D1 and the control of the circadian rhythms.
产品来源
洱畔科技实验室